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Why AI Could Change Women’s Health Forever (and the Secret to Using It Now)

The friendship hormone, why everyone is talking about fiber, new cool eyedrops and an insider invite for my readers only 🎉

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Jackie's Take: What's on My Mind in Women's Wellness ✍️ 🤔 📰 

🧬 The AI Revolution in Women’s Health — And Why It Matters for You

I had one of those moments this week where I literally said out loud: are you kidding me?

OpenAI’s new GPT-5 just scored 95 percent on clinical medical questions and 70 percent on complex reasoning tasks. Translation: AI is now better at answering medical exam questions than most doctors. It can analyze labs, connect symptoms, even interpret imaging with near-perfect precision. (For those who want to geek out, you can read the paper here).

And yet… when it comes to women’s health, it’s still serving up the same outdated advice we’ve been hearing for decades. Lowest dose, shortest time. Your labs are normal. It’s just stress. (If I had a dollar for every time a woman has heard that…)

Season 2 Ben GIF by Parks and Recreation

This hit me because it’s exactly what so many of us experience in real life. We’re leading in our careers, raising families, juggling everything — but our healthcare is still stuck on an outdated operating system. And that mismatch has consequences. Cardiovascular protection windows of opportunity left on the table. Bone health strategies delayed for years. Cognitive decline only addressed once it’s already underway.

Why this matters for us

I don’t share this to be dramatic. I share it because there’s also a massive opportunity hiding in plain sight here.

AI doesn’t have to be just another system that fails women. With the proper input and oversight (meaning expert clinicians who actually treat midlife women every day) it can finally become the tool we’ve been waiting for.

Here’s how I think about it. AI is like a brilliant but untrained research assistant. On its own, it memorizes and repeats what’s in old textbooks. But with the right teacher, it can start offering personalized, data-driven insights that actually reflect your body — not some outdated “average patient.”

Here’s what that could look like for you

  • Your Whoop, Oura, or Apple Watch data translated into insights you can actually use (not just another rainbow graph you ponder and then ignore).

  • Supplement and hormone protocols adjusted in real time as your body changes, not once a year at your rushed annual visit.

  • An AI that actually adapts to you. Imagine using your Enneagram type to teach it how you like to learn, so the health info you get shows up in a way you’ll act on.

  • Working with a clinician who can connect the dots and use AI to sharpen wisdom and experience — not replace it.

That’s the part that makes me lean in. Not AI on its own, but AI in the hands of experts who understand women’s health and can finally push past the cookie-cutter advice.

Oura ring

Why this moment matters

Here’s the thing: this isn’t five years away. It’s already here. And there are plenty of tech companies out there right now who are building on top of it, betting you won’t be confident enough to use it yourself (boy, are they wrong).

So here is what I want you to know: the women who will come out ahead in the next decade are the ones who figure out how to make these tools work for them, guided by experts who understand the messy, nuanced reality of midlife biology. While most people are still fighting insurance for a basic hormone panel, you could be running an AI-assisted longevity strategy that adapts in real time. (Tell me that doesn’t sound better than another year of “watchful waiting.”)

The bottom line

The infrastructure exists. The expertise exists. The question is whether we’ll claim it for ourselves before it goes mainstream.

I know this much: our health is our most valuable asset. And the AI revolution in healthcare is happening whether we’re ready or not. The women who thrive won’t be the ones waiting around for the system to finally get it right. They’ll be the ones using it, strategically, to change the game now.

So let me ask you: if you had an AI wellness assistant trained specifically for perimenopause, what’s the first thing you’d want it to figure out for you?

Reply to this email and let me know! ✍️ (And no, sadly, I can’t program it to fold laundry or drive your kids to soccer… but wouldn’t that be nice?) 🧺 

Issa Rae Vip GIF by Insecure on HBO

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The Tea: What's Trending in Women's Wellness & Culture 🍵 📰 

VIZZ, a newly FDA-approved eye drop, improves age-related near vision loss by constricting the pupil to create a “pinhole effect.” One drop can deliver up to 10 hours of sharper focus, offering midlife women an alternative to reading glasses for daily tasks like work, reading, and makeup. The FDA approval is based on trial data submitted by the manufacturer, but peer-reviewed publications are still pending 👓️ (New Atlas)

Oxytocin isn’t just the “love hormone”—it might be the real friendship glue. And in midlife, when estrogen dips and connection becomes medicine, oxytocin is basically the longevity supplement no one’s bottling yet (sorry, collagen). So yes, your group chat really is good for your health. 📲 (UC Berkeley)

Turns out it’s not just what you eat but how processed it is. In a new study, people who skipped the shrink-wrapped, ultra-processed stuff and stuck to real, home-cooked meals lost nearly twice as much weight—and had fewer cravings along the way. 🥗 (NYT)

A Special Note from Jackie 🖇️ 

How much have you spent in the last two years trying to figure out why you feel terrible?

Functional medicine consults. Specialty labs. Supplements that promised everything and delivered nothing. Maybe even a concierge doctor who spent more time talking than listening.

Conservative estimate? Most women I meet have invested $5,000-$15,000 chasing answers that should have been obvious from day one.

Here's the truth: you already have 80% of the information you need to transform how you feel. It's hiding in your existing lab work, your symptoms, patterns, and yes—even in that drawer full of supplement bottles that "didn't work."

What you've been missing isn't more tests. It's the ability to see the connections.

That's exactly why I created something that's never existed before: a systematic approach that teaches high-performing women to become their own health strategists using AI-powered pattern recognition.

Imagine walking into your next doctor's appointment with:

  • Clear documentation of your symptom patterns and triggers

  • Personalized protocols based on YOUR unique biomarkers

  • Confidence to advocate for the care you actually need (and the resources to find that care!)

  • A long-term strategy that adapts as your body changes

No more throwing spaghetti at the wall. No more hoping the next practitioner will finally "get it." No more accepting "normal" when you feel anything but.

This isn't another course promising magical transformations. It's a practical skill set that puts you back in the driver's seat of your health — whether you're 37 or 57, whether your labs are "perfect" or concerning, whether you're working with an amazing medical team or feeling completely on your own.

I'm piloting this with just 50 women who are tired of being expensive science experiments and ready to become their own health advocates.

Get exclusive access before anyone else even knows this exists. Click the button below to get started!

👇️ 🔲 👇️ 

The Group Chat Edit 📲 👯‍♂️ 

👀 To Try: Peptides are ALL the rage right now. I’m eyeing these Hair Growth Peptide Gummies that work by supporting follicle anchoring and reduce hair loss by up to 47% in 90 days (or so they say?). LMK if you try them!

 

👂️To Listen: This episode of the World’s First Podcast to find out why “Everyone’s Talking About Fiber (with Dr. Will Bulsiewicz)

🛍️ To Try: Tap into your nervous system and hack your HRV for better sleep with this vagus stimulator 🛌 

Saddle Up & Spread the Word 🏇💨

If you’re still reading, thank you. In the early days of a business, every subscribe, like, and share makes a real difference. Your early support means so much as I keep building In the Saddle - both the newsletter and this community ⭕️ 

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Collaborate / Sponsor This Newsletter

If you’re a brand, expert, or just someone with an excellent story to tell in the wellness, longevity, or sexual health space, I’d love to connect! I am always open to hearing ideas for ITS content and collabs. ✏️ 🏇🔥

With gratitude always,

Jackie Giannelli, FNP-BC, MSCP

Founder, In the Saddle

Medical Disclaimer:
The content provided in this newsletter is for informational and educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Nothing contained herein should be construed as medical guidance or the practice of medicine. You should always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment. Never disregard professional medical advice or delay seeking care because of something you read in this newsletter. Use of the information provided is at your own risk. No clinician-patient relationship is formed through this content.

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