Jackie's Take: What's on My Mind in Women's Wellness ✍️ 🤔 📰 

Just a Pinch of Ozempic, Please 💉 

A friend called me this week with a question she whispered like a secret:

She’s not alone. That question is in the back of everyone’s mind, floating in the cultural ether like a rogue TikTok sound. It’s the subject of hushed conversations at dinner parties and the silent thought you have while scrolling through Instagram in bed. 🤫 

The world has been buzzing about GLP-1s for a while now (the drug class that includes Ozempic and Zepbound), but the latest term being thrown around is microdosing.

It reminds me of that viral clip of the comedian trying to get just a tiny bit of Ozempic from her friend—not for major weight loss, but for that little edge. And just this week, I saw Andy Cohen casually drop in an interview that microdosing is working for him and has made him more “health conscious”. When Bravo’s king of normalization is talking about it on camera, you know the conversation has officially gone mainstream. 📺️ 

That’s the shift we’re living in. What was once a clinical tool is now a cultural talking point—equal parts curiosity, confusion, and quiet desire.

As a board-certified menopause and midlife specialist, I’ve seen this conversation evolve firsthand (I prescribed my first GLP to a patient during the pandemic and was blown away). And frankly, it’s moving faster than the medical establishment can keep up with, leaving many of you with more questions than answers.

That’s why I’m creating a special 3-part miniseries for this newsletter, designed to be binged like your favorite show (mine is Platonic right now—the chemistry is just unbeatable). We’re going to cut through the noise and have an honest, science-backed conversation about what this all means for women in midlife. 🗣️ 

Here’s the plan (so get excited 🪩🥳):

• Part 1: The What.
  What exactly is microdosing? What are the “rules”? What is a peptide? What is the difference between semaglutide and tirzepatide? What is a compounding pharmacy? What are research peptides and how do they differ from pharma-grade peptides? We’ll cover the cultural context, the costs, and the foundational questions you need to ask before even considering it.

• Part 2: The Why.
  This is where we get into the science. Why should midlife women, even those not focused on weight loss, pay attention? We’ll explore the intersection of GLP-1s with hormone therapy, metabolic health, and longevity, weighing the real pros and cons.

• Part 3: The How.
  How do you talk to your doctor (especially if you’re worried about being dismissed)? How can you access these treatments safely? How do you navigate conversations with friends and family? How do you combine this with hormone therapy?

My goal here at In the Saddle is always to give you the medically sound, insider information you can’t get anywhere else. This is the conversation you wish you could have with your doctor—one that’s smart, empathetic, and free of judgment. And I want to make sure it’s EXACTLY what you are interested in.

So with that said, please tell me below (click one of the buttons) 🐎 🔽 

One More Ask 🙏 

If you have a friend who’s been whispering the same question, share this newsletter with her and let her know whats about to go down.

Copy and paste this link right into your group chat:

👉 https://www.inthesaddlenewsletter.com/subscribe

Because this conversation? It’s better when we have it together.

Let’s do this,
Jackie ❣️ 

The Tea: What's Trending in Women's Wellness & Culture 🍵 📰 

💪 The New Status Symbol Isn’t a Handbag on your Arm, It’s Your Actual Arm
Strong is in. Weightlifting is surging as women chase muscle for longevity and bone health. But the new ideal—thin and visibly muscular—still feels unattainable for most, requiring resources few have. Strength is worth celebrating, but please don’t let another impossible standard define you. (Time)

🗣️ Is Menopause Changing Your Voice?
Yes, estrogen loss can alter vocal tissue folds, making midlife voices deeper or hoarser. For teachers, singers, or anyone using their voice professionally, that shift can be career-changing. Menopause doesn’t spare a single system, and our voices deserve the same research and respect. (Northeastern University)

❤️‍🩹 The “Other” Heart Attacks That Are Often Missed In Women
A new study shows that over half of heart attacks in women under 65 aren’t due to clogged arteries—they’re often due to tiny clots, spasms in the blood vessels or other overlooked causes. Symptoms more common in women like nausea or indigestion get often dismissed. Reminder: be your own advocate. Heart disease in women rarely looks textbook. (Women’s Health)

📱Women’s Sexual Health Breaks into the TikTok Shop (Finally!)
ED ads are everywhere, but women’s health still gets censored. Wisp just became the first sexual wellness brand to launch on TikTok Shop (starting with UTI relief, hey it’s something). The point? Sexual wellness is women’s health and accessing products and services should be as easy to access as anything else in your cart. (BeautyMatter)

I have to stop and THANK YOU💌 

You guys, I’m truly floored by the overwhelming response to The Longevity Lab—thank you. Next week, we kick off with an incredible group of women who are ready to reclaim their vitality, sharpen their focus, and step into midlife with power, pleasure, and confidence.

Your interest and support mean the world, and while this first cohort is full, I’d love for you to be part of what’s next. If you want to join us, add your name to the waitlist below (we’re just getting started). Let’s make 2026 the year to Biohack Like A Girl™️.

The Group Chat Edit 📲 👯‍♂️ 

🛍️ To Buy: Still trying to hit those protein goals? This egg cooker makes it super easy to get the perfect hard boiled egg (6 of them!) for an after school snack or your morning commute 🫠🥚 

📺️ To Watch: Platonic Former best friends Sylvia (Rose Byrne) and Will (Seth Rogen) reconnect after a long rift in midlife and the chemistry is “chef’s kiss”👩‍🍳.

👀 To Try: This woman asked for “unhinged” automated life hacks and the internet delivered! 🚚