Jackie's Take: What's On My Mind in Women's Wellness ✍️
You've seen the sticker. "BPA-free," right there on the water bottle, the blender cup, the kid's snack container. You bought that one on purpose, because you did the research and you were trying to do the right thing.
So here's the sticky part: "BPA-free" isn't a promise that the bottle is hormone safe. In fact, it only promises that one specific molecule isn't in it.
It says nothing about what got used instead.
Disappointingly (but not surprisingly) what got used instead is usually a chemical cousin to BPA that behaves almost exactly the same way in your body.
When BPA got a bad reputation, manufacturers reached for the two nearest replacements, BPS and BPF. Same family, similar shape.
There's actually a name for this move: "regrettable substitution." You swap a chemical of concern for a barely-tested lookalike, print a reassuring label, and move on. The public-relations problem is solved. The health one is not.
The peer-reviewed literature comparing these substitutes found them to be similarly hormonally active to the BPA they replaced. So that means "BPA-free" can still mean bisphenol-something, and the something isn't necessarily better. One researcher called the whole cycle a game of chemical whack-a-mole, and that is exactly what it is.
I care about this more than the average person does, because I treat women whose hormones are already in motion. In your late 30s and 40s, your progesterone and estrogen are fluctuating week to week on their own. Drop in a compound that mimics estrogen at the receptor and things can get unnecessarily complicated.
Luckily, the fix isn't complicated.
"What's the biggest health question mark in your house right now?"
The LAiDY Edit 🤖
Here's a job I'd hand to AI this week: sorting your entire food-storage cabinet in about 30 seconds, without pulling a single thing out.
Open the cabinet where your containers and water bottles live. Take one photo. Upload it to your AI of choice and say:
"You're a materials-savvy women's health clinician, not a salesperson. Here's a photo of my food-storage cabinet. Tell me which items are worth swapping to glass or stainless steel first, especially anything I microwave, put hot food in, or reuse every day. Rank them most-to-least worth changing, and tell me which ones are genuinely fine to keep. Don't make me replace things that don't matter."
What I love about this: it does the sorting you've been avoiding. Instead of standing there overwhelmed, you get a short ranked list (swap these two, leave the rest) in the time it takes to find your keys. And because you told it not to over-flag, it won't have you tossing a perfectly fine pasta bin.
The usual caveat: AI can get the specifics wrong, so treat its list as a smart first pass, not a verdict. When it flags something, check the recycling number on the bottom yourself before you toss it.
This is a tiny version of what I'm teaching this fall: hand AI your real life and get an answer built around your actual symptoms and labs, not a generic checklist. Join the waitlist here.
Worth the Click 🔗
Six couples, a whole lotta plastic, and infertility.
The Plastic Detox (Netflix, 2026) follows six couples with unexplained infertility as they work to lower their plastics exposure. It's a rare mainstream look at the thing I keep pointing to: these chemicals don't act on us one at a time, they act as a cumulative load, and reproductive and hormone health is where the effect shows up.
The Find 🛍️
Remember the weighted vest I tried on at Tamsen Fadal's apartment back in May? I've been wearing mine ever since, and it has officially graduated from "fun find" to "thing I reach for on autopilot."
After 40, your muscles and bones respond to load, and most of us only give them any during an actual workout. A vest turns the walking you already do into load-bearing time. Same errands or chores, more stimulus, zero extra minutes.
The YVO vest is the one I recommend because it was designed around a woman's frame. The soft weights sit flat against you instead of digging in, and you can start with the 10 lb set and build from there. And the part I love as a clinician: every vest comes with a free DEXA scan, so you start with a real baseline instead of a guess.
Affiliate disclosure: I have a partnership with YVO, and if you buy through my code I may earn a small commission at no extra cost to you. I only recommend products I would tell a patient to use.
Saddle Up & Spread the Word 🏇💨

If this issue made you turn your water bottle over to check the bottom, forward it to the friend who's still buying plastic water bottles in bulk. That's how In the Saddle grows, one well woman at a time.
To share — Just click and copy this link: https://inthesaddle.beehiiv.com/
If you’re a brand, expert, or just someone with an excellent story to tell in the wellness, longevity, or sexual health space, I’d love to connect! I am always open to hearing ideas for ITS content and collabs. ✏️ 🏇🔥
With gratitude always,
Jackie Giannelli, FNP-BC, MSCP
Founder, In the Saddle
Medical Disclaimer:
The content provided in this newsletter is for informational and educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Nothing contained herein should be construed as medical guidance or the practice of medicine. You should always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment. Never disregard professional medical advice or delay seeking care because of something you read in this newsletter. Use of the information provided is at your own risk. No clinician-patient relationship is formed through this content.
*This newsletter may contain affiliate links. If you choose to purchase through these links, I may earn a small commission at no additional cost to you. All recommendations are my own, and I only share products I personally use or trust.


